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pentobarbital decreases effects of sufentanil SL by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of CYP3A4 inducers may well lower sufentanil concentrations and efficacy, probably precipitating withdrawal syndrome in people that have made Bodily dependence to sufentanil. Discontinuation o
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